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Steam

Patient Zero

Also known as Patient Zero, patient zero, patient-zero

Patient Zero is a randomly generated twin-stick shooter game with great emphasis on its roguelike elements. it takes its inspiration from 80s sci-fi and action movies. You play as one of the hazmat crew enlisted in a top-secret adventure to find Patient Zero and stop another deadly virus.

Last update
18 May 2026
Original sources
1
Latest update
Announcement

Patient Zero Dev Playthrough and Q&A

come watch Nathan Prince play Patient Zero and answer some of your questions if you have any. plus I will be sharing the future of the game and what's next for Patient Zero

Latest updates

Update history

Browse past updates and patch notes for this game.

2updates

Gallery

In-game media